Dear Sir, I have studied some evaluation bioassay methods. In some cases they are more realistist that the included in the present version of the draft this document. They are descrited (some examples of this draft are studied) in Sánchez G; “Fitting bioassay data and performing uncertainty analysis with BIOKMOD” Health Physics.. 92(1) :64-72. 2007. ISSN/ISBN: 0017-9078. G. Sánchez; J. M. Rodríguez-Díaz . Optimal design and mathematical model applied to establish bioassay programs”: Radiation Protection Dosimetry. doi:10.1093/rpd/ncl499. 2007. ISSN/ISBN: ISSN 1742-3406 I will appreciate they have been taken account in the final version of this document "Interpretation of bioassay data". At least I would some reference be included. Guillermo Sanchez